Lobelia inflata, also known as Indian tobacco or puke weed, is a species of Lobelia native to eastern North America, from southeastern Canada (Nova Scotia to southeast Ontario) south through the eastern United States to Alabama and west to Kansas.

Lobelia inflata has a long use as a medicinal plant as an entheogenic, emetic, and skin or respiratory aid. Native Americans used it for respiratory and muscle disorders, as a purgative, and as a ceremonial medicine. The leaves were chewed and smoked. The plant was used as a traditional medicinal plant by the Cherokee, Iroquois, Penobscot, and other indigenous peoples. The foliage was burned by the Cherokee as a natural insecticide, to smoke out gnats.